Omtrent seven-9 % af den kaukasiske befolkning har variationer i CYP2D6 genet som koder for ingen- eller nedsat aktivitet af CYP2D6 (se personlig medicin ). Tramadol et produg der omdannes til den aktive metabolit by way of CYP2D6. Patienter med nedsat eller manglende aktivitet af CYP2D6, vil have reduceret- eller manglende effekt af tramadol.A les

I stedet passer de flittigt deres daglige misbrug af opioidpiller i det skjulte. Bare for at være i stand til at stå ud af sengen, møde op i skolen eller passe et fritidsarbejde.The opioid disaster is a results of numerous, intricate interrelated variables. A lot of doctors might not truly feel capable to appropriately take care of suffering and

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